Hoang IB, Munier JJ, Verghese A, Greer Z, Millard SJ, DiFazio LE, Sercander C, Izquierdo A, Sharpe MJ. In Review. A novel hypothalamic-midbrain circuits for model-based learning. PDF on bioRxiv


Millard SJ , Hoang IB, Greer Z, O’Connor SL, Wassum KM, James MH, Barker DJ, Sharpe MJ. In Revision. The cognitive basis of intracranial self-stimulation of dopamine neurons. PDF on bioRxiv.

Sias AC, Jafar Y, Goodpaster CM, Ramírez-Armenta K, Wrenn TM, Griffin NK, Sharpe MJ, Wassum KM. In revision. Dopamine projections to the basolateral amygdala drive the encoding of identity-specific reward memories. PDF on bioRxiv.

Gabriel CJ, Zeidler Z, Jin B, Guo C, Goodpaster CM, Kashay AQ, Wu A, Delaney M, Cheung J, DiFazio LE, Sharpe MJ, Aharoni D, Wilke SA, DeNardo LA. 2022. BehaviorDEPOT is a simple, flexible tool for automated behavioral detection based on markerless pose tracking. eLife, 11:e74314. PDF.

Kutlu MG, Zachry JE, Melugin PR, Cajigas S, Isiktas A, Siciliano CA, Schoenbaum G, Sharpe MJ, Calipari ES. 2022. Dopamine responses to neutral stimuli in the nucleus accumbens core change over experience to determine future associative learning. Nature Neuroscience, 25: 1071-1081. PDF.

Seitz BM, Hoang IB, Blaisdell AP, Sharpe MJ. 2022. Dopamine errors drive excitatory and inhibitory components of backward conditioning in an outcome-specific manner. Current Biology, 32. PDF.

DiFazio LE, Fanselow M, Sharpe MJ. 2022.The effect of stress and reward on the way we encode future fear memories. Behavioral Brain Research, 417. PDF.

Millard SJ, Bearden CE, Karlsgodt KH, Sharpe MJ. 2022. The prediction-error hypothesis of schizophrenia: New data point to circuit-specific changes in dopamine activity. Neuropsychopharmacology, 47:628. PDF.


Seitz BM, Blasdell AP, Sharpe MJ. 2021. Higher-order cognition and dopamine: charting a path forward. Frontiers in Behavioral Neuroscience, 15. PDF.

Hoang IB, Sharpe MJ. 2021. The basolateral amygdala and lateral hypothalamus bias learning towards motivationally significant events. Current Opinion in Behavioral Sciences, 41, 92-97. PDF

Sharpe MJ, Batchelor HM, Mueller LE, Gardner MPH, Schoenbaum G. 2021. Past experience shapes the neural circuits recruited for future learning. Nature Neuroscience24(3), 391-400. PDF

Mueller LE, Sharpe MJ, Stalnaker TA, Wikenheiser AM, and Schoenbaum G. 2021. Prior cocaine use alters the normal evolution of informational encoding in striatal ensembles during value-guided decision making. Journal of Neuroscience. PDF


Sharpe MJ, Batchelor HM, Mueller LE, Chang CY, Maes EJP, Niv Y, Schoenbaum G. 2020. Dopamine transients do not act as model-free prediction errors during associative learning. Nature Communications, 11:106. PDF

Maes EJP, Sharpe MJ, Gardner MPH, Chang CY, Schoenbaum G, Iordanova MD. 2020. Causal evidence supporting the proposal that dopamine transients function as a temporal difference prediction error. Nature Neuroscience, 23:176. PDF

Hart EE, Sharpe MJ, Gardner MPH, Schoenbaum G. 2020. Responding to preconditioned cues is devaluation sensitive and requires orbitofrontal cortex during cue-cue learning. eLife, 9. PDF


Sharpe MJ, Stalnaker T, Schuck N, Killcross S, Schoenbaum G, Niv Y. 2019. An integrated model of action selection: distinct modes of cortical control of striatal decision making. Annual Review of Psychology, 70:53. PDF


Sharpe MJ, Killcross S. 2018. The modulation of attention and action in the medial prefrontal cortex of rats. Psychological Review, 125:822. PDF

Sharpe MJ, Schoenbaum G. 2018. Evaluation of the hypothesis that phasic dopamine constitutes a cached-value signal. Neurobiology of Learning and Memory, 153:131. PDF

Sharpe MJ, Schoenbaum G. 2018. Does the dopamine prediction error act like a cached-value error signal? In Goal Directed Decision Making: Computations & Neural Circuits, Morris R & Bornstein A (eds.), Elsevier. PDF

Sharpe MJ. 2018. What a relief! A role for dopamine in positive (but not negative) valence. Neuropsychopharmacology, 43:1. PDF

Langdon A, Sharpe MJ, Schoenbaum G, Niv Y. 2018. Model-based predictions for dopamine. Current Opinion in Neurobiology, 49:1. PDF


Sharpe MJ, Chang CY, Liu MA, Batchelor HM, Mueller LE, Jones JL, Niv Y, Schoenbaum G. 2017. Dopamine transients are sufficient and necessary to support the acquisition of model-based associative information. Nature Neuroscience, 20:735. PDF

Sharpe MJ, Batchelor HM, Schoenbaum G. 2017. Preconditioned cues have no value. eLife, 6. PDF

Sharpe MJ, Marchant NJ, Whitaker LR, Richie CT, Zhang YJ, Campbell EJ, Koivula PP, Necarsulmer JC, Meijas-Aponte C, Morales M, Pickel J, Smith JC, Niv Y, Shaham Y, Harvey BK, Schoenbaum G. 2017. Lateral hypothalamic GABAergic neurons encode reward predictions that are relayed to the ventral tegmental area to regulate learning. Current Biology, 27:2089. PDF

Nasser HM, Calu DJ, Schoenbaum G, Sharpe MJ. 2017. The dopamine prediction error: contributions to associative models of reward learning. Frontiers in Psychology (Cognition), 8:244. PDF


Sharpe MJ, Schoenbaum G. 2016. Back to basics: making predictions in the orbitofrontal-amygdala circuit. Neurobiology of Learning and Memory, 131:201. PDF

Sharpe MJ, Clemens KC, Morris M, Westbrook RF. 2016. Daily exposure to sucrose impairs subsequent learning about food cues: a role for alterations in ghrelin signaling and dopamine D2 receptors. Neuropsychopharmacology, 41:1357. PDF


Sharpe MJ, Wikenheiser AM, Niv Y, Schoenbaum G. 2015. The state of the orbitofrontal cortex. Neuron, 88:1075. PDF

Sharpe MJ, Killcross S. 2015. The prelimbic cortex directs attention towards predictive cues during fear learning. Learning and Memory, 22:289. PDF

Sharpe MJ, Killcross S. 2015. The prelimbic cortex uses contextual cues to modulate responding towards predictive cues during fear renewal. Neurobiology of Learning and Memory, 118:20. PDF

Sharpe MJ, Killcross S. 2015. The rodent prelimbic cortex uses higher-order cues to modulate both the acquisition and expression of conditioned fear. Frontiers in Systems Neuroscience, 8:235. PDF


Sharpe MJ, Killcross S. 2014. The prelimbic cortex contributes to the down-regulation of attention toward redundant cues. Cerebral Cortex, 24:1066. PDF


Sharpe MJ, Fardell JE, Vardy J, Johnston IN. 2012. The chemotherapy agent oxaliplatin impairs the renewal of conditioned fear to an extinguished conditioned stimulus in rats. Behavioral Brain Research, 227:295. PDF